These atypical characteristics can mimic other diseases, lead to misdiagnosis, and may require brain biopsy for diagnosis. One Mayo Clinic study found that 6% of all lesions with T2 hypointense borders on MRI were in fact tumefactive multiple sclerosis lesions. The more common pathologies included gliomas (40%), metastases (30%) and abscesses (8%).
Source : http://en.wikipedia.org/wiki/Tumefactive_multiple_sclerosis
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